News
APOE4 – Risks & Risk Management: A practical guide for those with the E4 variant of the APOE gene
- 08/05/2020
We proudly announce the second publication by our “Maximizing Health” initiative:
APOE4 – Risks & Risk Management
APOE is the gene responsible for coding Apolipoprotein E, a key player in our lipid metabolism. APOE comes in 3 significant variants: E2, E3 & E4.
The E4 variant is well known for its association with a significantly higher risk of Alzheimer’s disease. Numerous other conditions have been linked to it including different forms of dementia, cardiovascular disease, and decreased longevity. There are several important implications for carriers of one or two copies of the E4 variant, particularly concerning saturated fat and heavy metal detox.
To create this practical guide the team screened more than 800 scientific papers. We found that APOE4 was associated with significant negative effects in almost 20 categories including:
- Inflammation
- Lipid metabolism
- Fish oil
- Motor function
- Exercise
- Neurodegeneration & multiple sclerosis
- Traumatic brain injury
- Telomere length
- Heavy metal toxicity
- Cardiovascular disease
- Insulin resistance
- Glucose metabolism
- Sex
- Longevity
- Bone mineral density
- Gut microbiome
- Alcohol
- Cholesterol-lowering substances
- Evolutionary / Ancestral / Paleo style diets
We also propose a risk management strategy for APOE4 carriers based on the latest scientific publications.